Summary Report from the Royal College of Pathologists Forum: Rapid Genomic Testing for Cancer Patients
Publication Source: Royal College of Pathologists
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Accelerating Precision Medicine with Rapid Front-Line NGS
Publishing Entity: CAP Today Webinar
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oncoReveal Methylation Panels, Workflow and performance overview of targeted methylation NGS panels
Publication Source: Pillar Biosciences White Paper
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Detecting Ultra-Low Frequency ESR1 Mutations in Liquid Biopsy Samples Using the oncoReveal Essential LBx Panel
The oncoReveal® Essential LBx Panel is a single-tube, 34-gene amplicon-based NGS liquid biopsy assay built on SLIMamp® chemistry. Pillar tested it on Seraseq® ctDNA ESR1 reference standards diluted to 0.05% variant allele frequency (VAF) from 5–30 ng of plasma cell-free DNA (cfDNA), sequenced on the Illumina NextSeq 550 and analyzed with PiVAT® software. It detected these endocrine-therapy-resistance mutations in HR-positive breast cancer with 98.4% PPA at 0.1% VAF and 100% NPA — no molecular barcodes (UMIs) required.